Disinfectant and antiseptic
|Trade names||Betasept, ChloraPrep, Chlorostat, others|
|Topical, oral gel|
|Molar mass||505.45 g·mol−1|
|3D model (JSmol)|
|Melting point||134 to 136 °C (273 to 277 °F)|
|Solubility in water||0.8|
Chlorhexidine (CHX) (commonly known by the salt forms chlorhexidine gluconate and chlorhexidine digluconate (CHG) or chlorhexidine acetate) is a disinfectant and antiseptic that is used for skin disinfection before surgery and to sterilize surgical instruments. It may be used both to disinfect the skin of the patient and the hands of the healthcare providers. It is also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and to keep urinary catheters from blocking. It is used as a liquid or powder.
Side effects may include skin irritation, teeth discoloration, and allergic reactions. It may cause eye problems if direct contact occurs. Use in pregnancy appears to be safe. Chlorhexidine may come mixed in alcohol, water, or surfactant solution. It is effective against a range of microorganisms, but does not inactivate spores.
Chlorhexidine came into medical use in the 1950s. Chlorhexidine is available over the counter (OTC) in the United States. It is on the World Health Organization's List of Essential Medicines. In 2017, it was the 286th most commonly prescribed medication in the United States, with more than one million prescriptions.
Chlorhexidine is used in disinfectants (disinfection of the skin and hands), cosmetics (additive to creams, toothpaste, deodorants, and antiperspirants), and pharmaceutical products (preservative in eye drops, active substance in wound dressings and antiseptic mouthwashes). A 2019 Cochrane review concluded that based on very low certainty evidence in those who are critically ill "it is not clear whether bathing with chlorhexidine reduces hospital‐acquired infections, mortality, or length of stay in the ICU, or whether the use of chlorhexidine results in more skin reactions."
In endodontics, chlorhexidine is used for root canal irrigation and as an intracanal dressing, but has been replaced by the use of sodium hypochloritebleach in much of the developed world.
There is strong evidence that it is more effective than povidone-iodine and has been proven to kill 99.9% of germs in 30 seconds.
CHG is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts. It is particularly effective against Gram-positive bacteria (in concentrations ≥ 1 μg/l). Significantly higher concentrations (10 to more than 73 μg/ml) are required for Gram-negative bacteria and fungi. Chlorhexidine is ineffective against polioviruses and adenoviruses. The effectiveness against herpes viruses has not yet been established unequivocally.
Chlorhexidine, like other cation-active compounds, remains on the skin. It is frequently combined with alcohols (ethanol and isopropyl alcohol).
Use of a CHG-based mouthwash in combination with normal tooth care can help reduce the build-up of plaque and improve mild gingivitis. There is not enough evidence to determine the effect in moderate to severe gingivitis. About 20 mL twice a day of concentrations of 0.1% to 0.2% is recommended for mouth-rinse solutions with a duration of at least 30 seconds. Such mouthwash also has a number of adverse effects including damage to the mouth lining, tooth discoloration, tartar build-up, and impaired taste. Extrinsic tooth staining occurs when chlorhexidine rinse has been used for 4 weeks or longer.
Mouthwashes containing chlorhexidine which stain teeth less than the classic solution have been developed, many of which contain chelatedzinc.
Using chlorhexidine as a supplement to everyday mechanical oral hygiene procedures for 4 to 6 weeks and 6 months leads to a moderate reduction in gingivitis compared to placebo, control or mechanical oral hygiene alone.
Chlorhexidine is a cation which interacts with anionic components of toothpaste, such as sodium lauryl sulfate and sodium monofluorophosphate, and forms salts of low solubility and antibacterial activity. Hence, to enhance the antiplaque effect of chlorhexidine, "it seems best that the interval between toothbrushing and rinsing with CHX [chlorhexidine] be more than 30 minutes, cautiously close to 2 hours after brushing".
Chlorhexidine gluconate is used as a skin cleanser for surgical scrubs, as a cleanser for skin wounds, for preoperative skin preparation, and for germicidal hand rinses. Chlorhexidine eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
Chlorhexidine is very effective for poor countries like Nepal and its use is growing in the world for treating the umbilical cord. A 2015 Cochrane review has yielded high-quality evidence that within the community setting, chlorhexidine skin or cord care can reduce the incidence of omphalitis (inflammation of the umbilical cord) by 50% and also neonatal mortality by 12%.
CHG is ototoxic; if put into an ear canal which has a ruptured eardrum, it can lead to deafness.
CHG does not meet current European specifications for a hand disinfectant. Under the test conditions of the European Standard EN 1499, no significant difference in the efficacy was found between a 4% solution of chlorhexidine digluconate and soap. In the U.S., between 2007 and 2009, Hunter Holmes McGuire Veterans Administration Medical Center conducted a cluster-randomized trial and concluded that daily bathing of patients in intensive care units with washcloths saturated with chlorhexidine gluconate reduced the risk of hospital-acquired infections.
Whether prolonged exposure over many years may have carcinogenic potential is still not clear. The US Food and Drug Administration recommendation is to limit the use of a chlorhexidine gluconate mouthwash to a maximum of six months.
When ingested, CHG is poorly absorbed in the gastrointestinal tract and can cause stomach irritation or nausea. If aspirated into the lungs at high enough concentration, as reported in one case, it can be fatal due to the high risk of acute respiratory distress syndrome.
Mechanism of action
At physiologic pH, chlorhexidine salts dissociate and release the positively charged chlorhexidine cation. The bactericidal effect is a result of the binding of this cationic molecule to negatively charged bacterial cell walls. At low concentrations of chlorhexidine, this results in a bacteriostatic effect; at high concentrations, membrane disruption results in cell death.
It is a cationic polybiguanide (bisbiguanide). It is used primarily as its salts (e.g., the dihydrochloride, diacetate, and digluconate).
Chlorhexidine is deactivated by forming insoluble salts with anionic compounds, including the anionic surfactants commonly used as detergents in toothpastes and mouthwashes, anionic thickeners such as carbomer, and anionic emulsifiers such as acrylates/C10-30 alkyl acrylate crosspolymer, among many others. For this reason, chlorhexidine mouth rinses should be used at least 30 minutes after other dental products. For best effectiveness, food, drink, smoking, and mouth rinses should be avoided for at least one hour after use. Many topical skin products, cleansers, and hand sanitizers should also be avoided to prevent deactivation when chlorhexidine (as a topical by itself or as a residue from a cleanser) is meant to remain on the skin.
The structure is based on two molecules of proguanil, linked with a hexamethylenediaminespacer.
Chlorhexidine topical is sold as Betasept, Biopatch, Calgon Vesta, ChloraPrep One-Step, Dyna-Hex, Hibiclens, Hibistat Towelette, Scrub Care Exidine, Spectrum-4 among others.
Chlorhexidine gluconate mouthwash is sold as Dentohexinm, Paroex, Peridex, PerioChip, Corsodyl and Periogard, among others.
Hexoralettene N contains benzocaine, menthol and chlorhexidine hydrochloride. It is used as oral antiseptic candies.
The name "chlorhexidine" breaks down as chlor(o) + hex(ane) + id(e) + (am)ine), is a cationic polybiguanide. It is used primarily as its gluconate salt.
In animals, chlorhexidine is used for topical disinfection of wounds, and to manage skin infections. Chlorhexidine-based disinfectant products are used within the dairy farming industry.
Post-surgical respiratory problems have been associated with the use of chlorhexidine products in cats.
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Disinfectants: Igbo translation, definition, meaning, synonyms, pronunciation, transcription, antonyms, examples
The rules were strict: no undue flushing, and plenty of sheep - dip disinfectant .
A perfect disinfectant would also offer complete and full microbiological sterilisation, without harming humans and useful form of life, be inexpensive, and noncorrosive.
At the conclusion of the whipping, the prisoner's lacerated back was normally rinsed with brine, which served as a crude and painful disinfectant .
Embalming chemicals are a variety of preservatives, sanitizers, disinfectant agents, and additives used in modern embalming to temporarily delay decomposition and restore a natural appearance for viewing a body after death.
Despite my deep love of chess, lasers and aerosol disinfectant , I must forfeit.
Prior to the introduction of modern antibiotics, colloidal silver was used as a germicide and disinfectant .
John Twumasi, quoted earlier, reports: “I told the other tenants that our Society had sent us detergents and disinfectants—enough to clean the entire house.
Sunlight is said to be the best of disinfectants .
Are Fungicidal disinfectants (for example; against rhizoctonia or common scab) required for certification?
It is used in the manufacture of a wide variety of industrial and household chemicals and is a common ingredient in chemicals such as antiseptics, disinfectants , and detergents.
Together with Willoughby D. Miller, Newell Sill Jenkins developed a toothpaste and named it Kolynos, the first toothpaste containing disinfectants .
Air disinfectants are typically chemical substances capable of disinfecting microorganisms suspended in the air.
On 18 February, Foreign Minister Heiko Maas had 8.4 tons of protective gear and clothing as well as disinfectants sent to China.
Nail technicians use beauty products like nail polish, nail polish removers, artificial nails, adhesives, and disinfectants throughout the day.
Spor-Klenz® Ready-to-Use Sterilant
STERIS' Spor-Klenz® Ready-To-Use Cold Sterilant is a fast acting, liquid cold sterilant/disinfectant, filtered to 0.22 micron and specifically formulated for use in the sterilization and disinfection of hard environmental surfaces in Pharmaceutical, Medical Device, Biotech and Cosmetic manufacturing facilities. This product is a stabilized blend of peracetic acid, hydrogen peroxide, and acetic that provides fast, effective microbial control, including spores. All of the active ingredients are notified according to the European Union Biocidal Products Directive (BPD). Spor-Klenz Ready-To-Use Sterilant offers a low toxicity profile, requires no mixing or activation and is reusable for up to 14 days which reduces waste. Each lot is fully traceable and documented by a Certificate of Analysis including filtration and USP sterility.
HOW SPOR-KLENZ READY-TO-USE COLD STERILANT WORKS
STERIS' Spor-Klenz Ready-To-Use Sterilant is a liquid sporicide specifically formulated for sterilization and disinfection of hard environmental surfaces. It can be used straight out of the container and be applied manually, sprayed or fogged.
WHY SPOR-KLENZ READY-TO-USE COLD STERILANT?
- Ease of Use - Consistent dilution every time because no mixing or activation is required.
- Efficacy - Microbial control against bacteria, fungi, viruses, and bacteria spores proven using AOAC and EN protocols.
- Safety - Low toxicity profile to support worker safety.
- Convenience - Excellent material compatibility allows use on most environmental surfaces.
- Flexibility - Versatility of use as a sterilant, sporicide, disinfectant or sanitizer.
Hypericum oil has antiseptic and analgesic properties.
(Hypericum Oil, NCI Thesaurus)
Isopropanol is used in soaps and lotions as an antiseptic.
(Isopropyl Alcohol, NCI Thesaurus)
Topically, it is used as an antiseptic.
(Isopropyl Alcohol, NLM, Medical Subject Headings)
A chemical used in bleaches, dyes, cleansers, antiseptics, and disinfectants.
(Hydrogen peroxide, NCI Dictionary)
Hops oil has antimicrobial and antiseptic properties and is also reported to have diuretic and sedative effect.
(Hops Oil, NCI Thesaurus)
I stood motionless, a roll of antiseptic cotton in my hand unwinding and spilling itself down to the floor.
(The Sea-Wolf, by Jack London)
Hexylresorcinol is used as an antiseptic in mouthwashes and skin wound cleansers.
(Hexylresorcinol, NCI Thesaurus)
Red cedarwood oil is used as an insect repellant, expectorant, antiseptic, and fungicide.
(Juniperus Virginiana Oil, NCI Thesaurus)
The lithium salt form of benzoic acid with diuretic and urinary antiseptic activity.
(Lithium Benzoate, NCI Thesaurus)
A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity.
(Nalidixic Acid, NCI Thesaurus)
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"Lamb in the spring, snow in the winter." (Armenian proverb)
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.How To Say Disinfectants
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